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Salut, il suffit de reprendre la formule qui est : T1/2 = ln(2) x Vd/Cl

 

Comme on a la clairance au dénominateur ça signifie que quand cette dernière augmente, le T1/2 diminue et inversement. 

 

La clairance, c’est l’élimination du médicament donc plus tu élimine de médicaments, plus vite tu atteindra la moitié de la concentration initiale et donc plus ta demi-vie sera petite/courte.

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