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Pharmacophores aspirine

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Go to solution Solved by rosembcéphale,

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rosembcéphale EsTATcion venanta !

rosembcéphale

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coucou,

 

en effet l'aspirine a deux sites pharmacologiquement actifs (=pharmacophores), à savoir : 

  • le radical acétyl : se lie de façon covalente à la sérine 530 de la COX1 
  • le radical COOH : se lie à l'arginine 120 de la COX par des liaisons ioniques 

 

j'espère que c'est plus clair pour toi ! 😊

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